Understanding Lupus Nephritis

For many, being diagnosed with lupus nephritis can feel overwhelming and discouraging. You might be thinking, “Living with lupus is hard enough! Now I have to deal with a whole new set of issues.” 

It’s true that even if you’ve been living with Systemic Lupus Erythematosus (SLE) for some time, there is more to understand about lupus once it affects the kidneys. Lupus nephritis poses its own set of challenges. Explore this section to learn more about lupus nephritis and its effects on both your health and day-to-day routine.

Fatigue Weight gain Foamy or frothy urine High blood pressure Swelling, usually in legs, feet, or ankles Who Develops It? Signs and Symptoms A Closer Look at LUPUS NEPHRITIS What Is It? A rare disease involving inflammation of the kidneys caused by Systemic Lupus Erythematosus (SLE). In lupus nephritis, the kidneys cannot function properly to remove waste from the blood and control the amount of fluids in the body. About ONE-THIRD have lupus nephritis at DIAGNOSIS Up to 5 OUT OF 10 develop lupus nephritis OVER TIME Approximately 1 IN 5 with lupus nephritis are thought to be UNDIAGNOSED In adults with SLE... Common early signs and symptoms: Compared to Caucasians, the prevalence of lupus nephritis is roughly: 4x HIGHER for African Americans and Asians 2x HIGHER for Hispanics and Native Americans There is a HIGHER PREVALENCE of lupus nephritis among specific RACIAL/ETHNIC groups Key Feature of Lupus Nephritis: Higher than normal levels ofPROTEIN IN THE URINE (a condition known as proteinuria) Stay Connected. Stay Informed. What’s Next? Clinical Trials:New potential treatments specific to lupus nephritis are currently being investigated To learn more, visit:www.clinicaltrials.gov(Search “lupus nephritis”) 10%-30% develop kidney failure within 15 years of diagnosis 10%-30% One study found that after 24 weeks of treatment, 9 out of 10 people still showed signs of kidney disease 9 out of 10 Impact on Health and WellbeingIn people with lupus nephritis... A Swedish study of 255 people with SLE showed that the impact on physical and emotional health is greatest when lupus affects the KIDNEYS Early Diagnosis and Treatmentof lupus nephritis may improvelong-term results TreatmentsTo date, no therapies have been approved by the U.S. Food and Drug Administration (FDA) or European Medicines Agency (EMA) for the treatment of lupus nephritis.Commonly used unapproved treatments may include: • Corticosteroids • Immunosuppressive therapy Aurinia does not promote or support the use of unapproved therapies for treatment of lupus nephritis. Diagnosis Tests used to diagnose lupus nephritis: Rheumatologist:Specialist who typically diagnoses lupus and lupus nephritis Nephrologist:Specialist who usually confirms lupus nephritis diagnosis through kidney biopsy Urine Test Blood Test Kidney Biopsy Always speak to your physician if you have any questions. Medical expenses are 4X higherthan for people with lupus alone Sign up to receive news and updates from ALL IN about lupus nephritis. Register now

Guide to Talking with Your Doctor

Make the most of your healthcare appointments. Download this helpful discussion guide and bring it with you to your next doctor’s visit.

Download Guide

Stay Connected. Stay Informed.

Sign up to receive:

  • Ongoing news and updates about lupus nephritis
  • A USB drive that contains helpful printable resources

Register Now