Understanding Lupus Nephritis

For many, being diagnosed with lupus nephritis can feel overwhelming and discouraging. You might be thinking, “Living with lupus is hard enough! Now I have to deal with a whole new set of issues.” 

It’s true that even if you’ve been living with Systemic Lupus Erythematosus (SLE) for some time, there is more to understand about lupus once it affects the kidneys. Lupus nephritis poses its own set of challenges. Explore this section to learn more about lupus nephritis and its effects on both your health and day-to-day routine.

Stay Connected. Stay Informed.Sign up to receive news and updates about lupus nephritis. Register Now What’s Next?Clinical Trials:New potential treatments specific to lupus nephritis are currently being investigated To learn more, visit:www.clinicaltrials.gov(Search “lupus nephritis”) A Swedish study of 255 people with SLE showed that the impact on physical and emotional health is greatest when lupus affects the KIDNEYS Medical expenses are 4X higherthan for people with lupus alone 10-30% develop kidney failure within 15 years of diagnosis 10-30% One study found that after 24 weeks of treatment, 9 out of 10 people still showed signs of kidney disease 9 out of 10 Impact on Health and WellbeingIn people with lupus nephritis... Early Diagnosis and Treatmentof lupus nephritis may improve long-term results TreatmentsTo date, no therapies have been approved by the U.S. Food and Drug Administration (FDA) or European Medicines Agency (EMA) for the treatment of lupus nephritis.Commonly used unapproved treatments may include: • Corticosteroids • Immunosuppressive therapy Aurinia does not promote or support the use of unapproved therapies for treatment of lupus nephritis. Diagnosis Tests used to diagnose lupus nephritis: Rheumatologist:Specialist who typically diagnoses lupus and lupus nephritis Nephrologist:Specialist who usually confirms lupus nephritis diagnosis through kidney biopsy Urine Test Blood Test Kidney Biopsy Always speak to your physician if you have any questions. Signs and SymptomsCommon early signs and symptoms: Fatigue Weight gain Foamy or frothy urine High blood pressure Swelling, usually in legs, feet, or ankles 100% of people with lupus nephritis have high levels ofPROTEIN IN THE URINE (a condition known as proteinuria) Compared to Caucasians, the prevalence of lupus nephritis is roughly: Who Develops It?In adults with SLE, approximately...ONE-THIRD have lupus nephritis at DIAGNOSIS3 OUT OF 5 develop lupus nephritis OVER TIME1 IN 5 with lupus nephritis are thought to be UNDIAGNOSEDThere is a HIGHER PREVALENCE of lupus nephritis among specific RACIAL/ETHNIC groups 4x HIGHER for African-Americans and Asians 2x HIGHER for Hispanics and Native Americans PrevalenceAffects an estimated 200,000 Americans 200,000 What Is It? An inflammation of the kidneys caused by Systemic Lupus Erythematosus (SLE). In lupus nephritis, the kidneys cannot function properly to remove waste from the blood and control the amount of fluids in the body. A Closer Look at LUPUS NEPHRITIS

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